Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene
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Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene
Ovarian cancer is the leading cause of death from all gynecological cancers and conventional therapies such as surgery, chemotherapy, and radiotherapy usually fail to control advanced stages of the disease. Thus, there is an urgent need for alternative and innovative therapeutic options. We reason that cancer gene therapy using a vector capable of specifically delivering an enzyme-encoding gene...
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Gene therapy has become a promising alternative treatment form for cancer. Among the broad range of different genetic means to reduce the tumor growth, herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) suicide gene therapy regimen is the best known approach. In this type of therapy, cancer cells are manipulated to express HSV-TK, followed by administration of the prodrug, the antiv...
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__________________________________________________________________________________________________ Correspondence: Naoto Adachi, MD&PhD. Department of Neurosurgery, Yamaguchi University School of Medicine, MinamiKogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan. Tel +81-836-22-2295; Fax +81-836-22-2294; E-mail [email protected] Abbreviations: HSV-TK, herpes simplex virus thymidine kin...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0040983